ULBP2 anticorps

N° du produit ABIN7076145

Détail du produit anti-ULBP2 anticorps

Antigène: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ULBP2 est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Human ULBP2

Information d'application

Indications d'application: WB (H) 1:500- 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur ULBP2

Antigène: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Autre désignation: ULBP2 (ULBP2 Produits)

Synonymes: anticorps N2DL2, anticorps RAET1H, anticorps UL16 binding protein 2, anticorps NKG2D ligand 2-like, anticorps ULBP2, anticorps LOC100355436

Sujet: ULBP2 is a human ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. The interaction with UL16 blocks the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. ULBP2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.

Poids moléculaire: 37 kDa

ID gène: 80328

NCBI Accession: NP_079493

UniProt: Q9BZM5