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WEE2 anticorps

WEE2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7076224
  • Antigène Voir toutes WEE2 Anticorps
    WEE2 (WEE1 Homolog 2 (S. Pombe) (WEE2))
    Reactivité
    • 27
    • 9
    Humain
    Hôte
    • 27
    Lapin
    Clonalité
    • 27
    Polyclonal
    Conjugué
    • 10
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp WEE2 est non-conjugé
    Application
    • 19
    • 18
    • 13
    • 2
    • 2
    • 1
    Western Blotting (WB)
     Réactivité croisée
    Humain
    Purification
    Affinity purification
    Immunogène
    KLH conjugated Synthetic peptide corresponding to Mouse WEE2
    Top Product
    Discover our top product WEE2 Anticorps primaire
  • Indications d'application
    WB (H) 1:300-1:600
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, pH 7.4, 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Antigène
    WEE2 (WEE1 Homolog 2 (S. Pombe) (WEE2))
    Autre désignation
    WEE2 (WEE2 Produits)
    Synonymes
    anticorps Xe-wee1, anticorps wee1, anticorps wee1-b, anticorps wee1a, anticorps wee1b, anticorps wee2-b, anticorps xwee1, anticorps xwee2, anticorps WEE1B, anticorps Gm1065, anticorps Wee1B, anticorps WEE2, anticorps im:5913035, anticorps si:ch211-238n5.5, anticorps wu:fi13b10, anticorps zgc:123074, anticorps WEE1 homolog 2, anticorps WEE1 homolog 2 (S. pombe), anticorps wee2, anticorps WEE2, anticorps Wee2
    Sujet
    WEE2, also named as WEE1B, belongs to the protein kinase superfamily. Ser/Thr protein kinase family and WEE1 subfamily. It phosphorylates and inhibits CDK1. WEE2 may act as a negative regulator of entry into mitosis (G2 to M transition). WEE2 is conserved from yeast to humans. The aim of the present study was to determine the spatiotemporal expression pattern and the function of WEE2 during oocyte maturation in a nonhuman primate species, the rhesus macaque. Taking the long double-stranded RNA-mediated RNA interference approach, down-regulation of WEE2 led to meiotic resumption in a subset of GV oocytes even in the presence of a phosphodiesterase 3 inhibitor. Overexpression of WEE2 delays the reentry of oocytes into meiosis in both mice and monkeys. WEE2 is a conserved oocyte-specific meiosis inhibitor that functions downstream of cAMP in nonhuman primates.
    Poids moléculaire
    62 kDa
    ID gène
    381759
    UniProt
    Q66JT0
    Pathways
    M Phase
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