WEE2 anticorps
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- Antigène Voir toutes WEE2 Anticorps
- WEE2 (WEE1 Homolog 2 (S. Pombe) (WEE2))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp WEE2 est non-conjugé
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Application
- Western Blotting (WB)
- Réactivité croisée
- Humain
- Purification
- Affinity purification
- Immunogène
- KLH conjugated Synthetic peptide corresponding to Mouse WEE2
- Top Product
- Discover our top product WEE2 Anticorps primaire
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- Indications d'application
- WB (H) 1:300-1:600
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
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- Antigène
- WEE2 (WEE1 Homolog 2 (S. Pombe) (WEE2))
- Autre désignation
- WEE2 (WEE2 Produits)
- Synonymes
- anticorps Xe-wee1, anticorps wee1, anticorps wee1-b, anticorps wee1a, anticorps wee1b, anticorps wee2-b, anticorps xwee1, anticorps xwee2, anticorps WEE1B, anticorps Gm1065, anticorps Wee1B, anticorps WEE2, anticorps im:5913035, anticorps si:ch211-238n5.5, anticorps wu:fi13b10, anticorps zgc:123074, anticorps WEE1 homolog 2, anticorps WEE1 homolog 2 (S. pombe), anticorps wee2, anticorps WEE2, anticorps Wee2
- Sujet
- WEE2, also named as WEE1B, belongs to the protein kinase superfamily. Ser/Thr protein kinase family and WEE1 subfamily. It phosphorylates and inhibits CDK1. WEE2 may act as a negative regulator of entry into mitosis (G2 to M transition). WEE2 is conserved from yeast to humans. The aim of the present study was to determine the spatiotemporal expression pattern and the function of WEE2 during oocyte maturation in a nonhuman primate species, the rhesus macaque. Taking the long double-stranded RNA-mediated RNA interference approach, down-regulation of WEE2 led to meiotic resumption in a subset of GV oocytes even in the presence of a phosphodiesterase 3 inhibitor. Overexpression of WEE2 delays the reentry of oocytes into meiosis in both mice and monkeys. WEE2 is a conserved oocyte-specific meiosis inhibitor that functions downstream of cAMP in nonhuman primates.
- Poids moléculaire
- 62 kDa
- ID gène
- 381759
- UniProt
- Q66JT0
- Pathways
- M Phase
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