ADAM17 anticorps (ADAM Metallopeptidase Domain 17) (AA 216-266)

Details for Product anti-ADAM17 Antibody No. ABIN705671
Antigène
  • ADAM18
  • CD156B
  • CSVP
  • NISBD
  • TACE
  • CD156b
  • Tace
  • adam17
  • si:dkey-81b15.2
  • adam18
  • cd156b
  • csvp
  • tace
  • fc20b01
  • wu:fc20b01
  • zgc:63886
  • ADAM metallopeptidase domain 17
  • a disintegrin and metallopeptidase domain 17
  • ADAM metallopeptidase domain 17b
  • ADAM metallopeptidase domain 17 L homeolog
  • ADAM metallopeptidase domain 17a
  • ADAM17
  • Adam17
  • adam17b
  • adam17.L
  • adam17a
Épitope
AA 216-266
63
19
15
11
10
9
8
8
7
6
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
243
95
86
2
2
1
1
1
1
1
Hôte
Lapin
207
22
21
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp ADAM17 est non-conjugé
14
10
7
6
6
5
4
4
4
4
4
4
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
195
121
45
38
24
13
11
11
10
7
5
3
2
1
1
1
Options
Immunogène KLH conjugated synthetic peptide derived from human ADAM17
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others ADAM17 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Adam17 (ADAM17 Antibody Extrait)
Sujet

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

Subcellular location: Extracellular

Synonyms: CSVP, TACE, NISBD, ADAM18, CD156B, NISBD1, Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, ADAM17

ID gène 6868
UniProt P78536
Pathways Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
Indications d'application WB 1:100-1000
FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 216-266) antibody (ABIN705671) Formalin-fixed and paraffin embedded human placenta labeled with Anti-ADAM17/CD156b P...
Flow Cytometry (FACS) image for anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 216-266) antibody (ABIN705671) Mouse thymocytes probed with Rabbit Anti-ADAM17 Polyclonal Antibody, Unconjugated .
Flow Cytometry (FACS) image for anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 216-266) antibody (ABIN705671) U937 cells probed with ADAM17 Polyclonal Antibody, Unconjugated at 1:100 for 30 min...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 216-266) antibody (ABIN705671) Paraformaldehyde-fixed, paraffin embedded rat kidney, Antigen retrieval by boiling in...
Produit citée dans: Li, Xie, He, Wang, Duan, Yang, Wang: "Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis." dans: Gene, Vol. 562, Issue 1, pp. 117-27, 2015 (PubMed). Méthode utilisée: Western Blotting (WB)

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