anticorps KNO, anticorps KNO1, anticorps KS, anticorps cb371, anticorps cb529, anticorps fc96d06, anticorps sb:cb529, anticorps wu:fb47h10, anticorps wu:fb77g12, anticorps wu:fc50f04, anticorps wu:fc96d06, anticorps wu:fk02h12, anticorps kno, anticorps kno1, anticorps collagen type XVIII alpha 1 chain, anticorps collagen type XVIII alpha 1 chain a, anticorps collagen, type XVIII, alpha 1, anticorps collagen type XVIII alpha 1, anticorps COL18A1, anticorps col18a1a, anticorps Col18a1, anticorps col18a1
Classe de substances
Chemical
Sujet
Synonyms:Endostatin Background:Endostatin is a naturally-occurring 20- kDa C-terminal fragment derived from COL18A1(also named as KNO). It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. It potently inhibits endothelial cell proliferation and inhibits endothelial cell angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Endostatin is a broad spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor(bFGF/FGF-2) and vascular endothelial growth factor(VEGF).