Retinoid X Receptor alpha anticorps

N° du produit ABIN7118450

L’anticorps Souris Monoclonal anti-Retinoid X Receptor alpha a été validé pour WB et ELISA. Il convient pour détecter Retinoid X Receptor alpha dans des échantillons de Humain et Souris.

Aperçu rapide pour Retinoid X Receptor alpha anticorps (ABIN7118450)

Antigène: Retinoid X Receptor alpha (RXRA) (Retinoid X Receptor, alpha (RXRA))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Retinoid X Receptor alpha est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 1A0

Détail du produit anti-Retinoid X Receptor alpha anticorps

Fonction: RXRA antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: retinoid X receptor, alpha

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:200-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Retinoid X Receptor alpha

Antigène: Retinoid X Receptor alpha (RXRA) (Retinoid X Receptor, alpha (RXRA))

Autre désignation: RXRA

Sujet:

Synonyms: Retinoic acid receptor RXR-alpha|Nuclear receptor subfamily 2 group B member 1|Retinoid X receptor alpha|RXRA|NR2B1

Background: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements(RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements(RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

Poids moléculaire: 44 kDa

ID gène: 6256

UniProt: P19793

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Hepatitis C