ROCK1 anticorps (rho-Associated, Coiled-Coil Containing Protein Kinase 1) (pThr455) (Biotin)

Details for Product anti-ROCK1 Antibody No. ABIN707773
Antigène
  • LOC100229794
  • CG9774
  • DROK
  • DRhk
  • DRok
  • Dmel\\CG9774
  • Drok
  • ROCK
  • ROCK-1
  • ROCK1
  • ROK
  • ROKalpha/beta
  • Rhk
  • RhoK
  • Rock
  • Rok
  • dROK
  • dRok
  • drok
  • 1110055K06Rik
  • Rock-I
  • P160Rock
  • ROCK-I
  • P160ROCK
  • p160ROCK
  • Rho associated coiled-coil containing protein kinase 1
  • Rho kinase
  • Rho-associated coiled-coil containing protein kinase 1
  • Rho-associated, coiled-coil containing protein kinase 1
  • ROCK1
  • Rok
  • Rock1
  • rock1
Épitope
pThr455, pSer456
26
23
15
9
7
5
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
149
106
100
9
4
4
4
1
1
1
Hôte
Lapin
135
15
Clonalité
Polyclonal
Conjugué
Cet anticorp ROCK1 est conjugé à/à la Biotin
5
5
5
5
5
4
4
4
3
3
3
3
3
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
100
41
37
36
21
16
12
12
7
3
3
2
2
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human ROCK1 around the phosphorylation site of Thr455/Ser456
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others ROCK1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Rock1 (ROCK1 Antibody Extrait)
Sujet

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.

Synonyms: ROCK-I, P16ROCK, Rho-associated protein kinase 1, Renal carcinoma antigen NY-REN-35, Rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, p16 ROCK-1, ROCK1

ID gène 6093
UniProt Q13464
Pathways Dynamique des Microtubules, Signalisation WNT, M Phase, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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