Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
Subcellular location: Cytoplasm
Synonyms: Cupidin, HOME2_HUMAN, HOMER 2, HOMER 2A, HOMER 2B, Homer homolog 2 Drosophila, Homer homolog 3, Homer neuronal immediate early gene 2, Homer protein homolog 2, Homer-2, Homer2, HOMER2A, HOMER2B, Vesl 2, Vesl2.