Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) anticorps (HRP)

Détails pour le produit réf. ABIN707855
Antigène
  • TAK1
  • TR2R1
  • TR4
  • hTAK1
  • Tr4
  • gb:dq017625
  • im:6911408
  • mKIAA4145
  • nuclear receptor subfamily 2 group C member 2
  • nuclear receptor subfamily 2, group C, member 2
  • NR2C2
  • Nr2c2
  • nr2c2
Reactivité
Humain, Souris, Rat (Rattus)
301
209
206
12
8
8
6
6
5
5
4
3
2
2
2
1
Hôte
Lapin
275
30
1
Clonalité
Polyclonal
Conjugué
HRP
16
14
14
14
14
14
14
8
8
6
6
6
6
6
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
191
79
75
73
42
8
5
2
2
1
1
1
1
Options
Immunogène KLH conjugated synthetic peptide derived from human NR2C2/TAK1
Isotype IgG
Specificité This antibody may have a minor secondary cross-reactivity towards NR2C1 in human and rat, based upon a non-sequential 77 % sequence similarity over the immunogen range.
Purification Purified by Protein A.
Antigène
Autre désignation Nr2c2/Tak1
Sujet

Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

Subcellular location: Nucleus

Synonyms: TR4, TAK1, Nuclear receptor subfamily 2 group C member 2, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, Testicular receptor 4, NR2C2

ID gène 7182
UniProt P49116
Pathways TCR Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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