GSK3 alpha anticorps (Glycogen Synthase Kinase 3 alpha) (AA 1-50) (HRP)

Details for Product anti-GSK3a Antibody No. ABIN708125
Antigène
  • 2700086H06Rik
  • GSK3A
  • GSK-3[a]
  • GSK-3[b]
  • GSK3
  • gsk3a
  • xgsk3
  • glycogen synthase kinase 3 alpha
  • glycogen synthase kinase 3 alpha b
  • glycogen synthase kinase 3 alpha S homeolog
  • GSK3A
  • Gsk3a
  • gsk3a
  • gsk3ab
  • gsk3a.S
  • Bm1_31380
Épitope
AA 1-50, pSer21
75
26
25
17
14
13
8
8
7
4
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
301
171
152
6
5
5
4
3
2
Hôte
Lapin
247
79
3
Clonalité
Polyclonal
Conjugué
Cet anticorp GSK3 alpha est conjugé à/à la HRP
20
16
9
7
7
7
7
7
7
6
6
6
4
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
260
142
132
52
35
35
13
10
8
7
6
3
3
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human GSK3 Alpha around the phosphorylation site of Ser21
Isotype IgG
Specificité This phosphorylation site is homologous to that of Ser21 in Mouse and Rat.
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others GSK3 alpha products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Gsk3 alpha (GSK3a Antibody Extrait)
Sujet

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

Synonyms: Glycogen synthase kinase-3 alpha, GSK-3 alpha, Serine/threonine-protein kinase GSK3A, GSK3A

ID gène 2931
UniProt P49840
Pathways Signalisation PI3K-Akt, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
Avez-vous cherché autre chose?