CLDN14 anticorps (Claudin 14) (Biotin)

Details for Product anti-CLDN14 Antibody No. ABIN708553
Antigène
  • claudin-14
  • CLDN14
  • DFNB29
  • AI851731
  • claudin 14 L homeolog
  • claudin 14
  • cldn14.L
  • CLDN14
  • Cldn14
Reactivité
Humain, Souris, Rat (Rattus)
70
28
16
2
Hôte
Lapin
58
7
5
Clonalité
Polyclonal
Conjugué
Cet anticorp CLDN14 est conjugé à/à la Biotin
4
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
50
30
13
6
4
4
2
1
1
1
Options
Immunogène KLH conjugated synthetic peptide derived from human Claudin 14
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others CLDN14 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Claudin 14 (CLDN14 Antibody Extrait)
Sujet

The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecules. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-14 is a multi-pass membrane protein that is expressed in liver, kidney and ear. Defects in the gene encoding claudin-14 are the cause of non-syndromic sensorineural deafness autosomal recessive type 29 (DFNB29), a form of hearing loss resulting from damage to either nerve pathways or neural receptors of the inner ear.

Subcellular location: Extracellular

Synonyms: Claudin-14, CLDN14, DFNB29, Human CLDN14 gene, OTTHUMP00000109046, OTTHUMP00000109049, OTTMUSP00000021531, UNQ777/PRO1571.

Pathways Cell-Cell Junction Organization, Hepatitis C
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
Avez-vous cherché autre chose?