STAT1 anticorps (pSer727)

N° du produit ABIN7138687

Détail du produit anti-STAT1 anticorps

Antigène: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Épitope: pSer727

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAT1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine 727 (P-M-S(p)-P-E) derived from Human STAT1.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur STAT1

Antigène: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Autre désignation: STAT1 (STAT1 Produits)

Synonymes: anticorps CANDF7, anticorps ISGF-3, anticorps STAT91, anticorps 2010005J02Rik, anticorps AA408197, anticorps XStat1, anticorps STAT4, anticorps DD6G4-4, anticorps STAT, anticorps STAT1, anticorps dZ182H3.3, anticorps si:by134g18.2, anticorps si:by51f19.1, anticorps si:dz182h3.3, anticorps si:dz199m19.1, anticorps si:dz73o4.2, anticorps stat1, anticorps signal transducer and activator of transcription 1, anticorps signal transducer and activator of transcription 1 L homeolog, anticorps signal transducer and activator of transcription 1, 91kDa, anticorps signal transducer and activator of transcription 4, anticorps signal transducer and activator of transcription 1a, anticorps STAT1, anticorps Stat1, anticorps stat1.L, anticorps stat4, anticorps stat1a

Sujet:

Background: Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-a and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.

Yuan ZM, et al. (1999) Nature.399 (6738): 814-817.
Schindler C, et al. (1992) Proc. Natl. Acad. Sci. U.S.A 89:7836-7839.
Strausberg R.L (2002). Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903.
Quelle F.W., (1995) J. Biol. Chem. 270:20775-20780.

Aliases: Signal transducer and activator of transcription 1 91kD antibody, CANDF7 antibody, DKFZp686B04100 antibody, IMD31A antibody, IMD31B antibody, IMD31C antibody, ISGF 3 antibody, ISGF-3 antibody, OTTHUMP00000163552 antibody, OTTHUMP00000165046 antibody, OTTHUMP00000165047 antibody, OTTHUMP00000205845 antibody, Signal transducer and activator of transcription 1 91 kDa antibody, Signal transducer and activator of transcription 1 antibody, Signal transducer and activator of transcription 1, 91kD antibody, Signal transducer and activator of transcription 1-alpha/beta antibody, STAT 1 antibody, Stat1 antibody, STAT1_HUMAN antibody, STAT91 antibody, Transcription factor ISGF 3 components p91 p84 antibody, Transcription factor ISGF-3 components p91/p84 antibody, Transcription factor ISGF3 components p91/p84 antibody, XStat1 antibody

UniProt: P42224

Pathways: Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events