This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Synonyms: Chromosome 12 open reading frame 8, Endoplasmic reticulum lumenal protein ERp28, Endoplasmic reticulum protein 29, Endoplasmic reticulum protein 29 isoform 1, Endoplasmic reticulum protein ERp29, ERp28, ERp31, PDI-DB, C12orf8.