FZD7 anticorps (Frizzled Family Receptor 7) (AA 550-574) (Cy5.5)

Details for Product anti-FZD7 Antibody No. ABIN710056
Antigène
  • FzE3
  • Fz-7
  • Xfz7
  • frizzled-7
  • frizzled7
  • frz-7
  • frz7
  • fz7
  • fzd7-a
  • fzd7-b
  • fze3
  • Fz7
  • cFz-7
  • fb38g02
  • fc44b09
  • fz13
  • fz7a
  • fz7b
  • wu:fb38g02
  • wu:fc44b09
  • zg13
  • frizzled class receptor 7
  • frizzled class receptor 7 L homeolog
  • frizzled class receptor 7b
  • FZD7
  • fzd7.L
  • fzd7
  • Fzd7
  • fzd7b
Épitope
AA 550-574
24
19
14
12
10
8
8
7
6
2
2
2
2
2
2
2
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
103
83
25
6
5
4
4
3
2
2
1
1
1
1
Hôte
Lapin
108
12
11
7
Clonalité
Polyclonal
Conjugué
Cet anticorp FZD7 est conjugé à/à la Cy5.5
9
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
102
63
21
18
12
12
4
2
2
1
1
1
Options
Immunogène KLH conjugated synthetic peptide derived from human Frizzled 7
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others FZD7 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Frizzled 7
Sujet

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular location: Cytoplasm

Synonyms: FzE3, Frizzled-7, Fz-7, hFz7, FZD7

ID gène 8324
UniProt O75084
Pathways Signalisation WNT, Stem Cell Maintenance
Indications d'application IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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