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MAPK7 anticorps (pSer496)

MAPK7 Reactivité: Humain, Souris WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN710246
  • Antigène Voir toutes MAPK7 Anticorps
    MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))
    Épitope
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 15
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer496
    Reactivité
    • 88
    • 61
    • 56
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Souris
    Hôte
    • 119
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 112
    • 11
    Polyclonal
    Conjugué
    • 42
    • 10
    • 9
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    Cet anticorp MAPK7 est non-conjugé
    Application
    • 76
    • 53
    • 52
    • 42
    • 24
    • 22
    • 16
    • 12
    • 8
    • 5
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain, Souris
    Homologie
    Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic phosphopeptide derived from human ERK5 around the phosphorylation site of Ser496 [GP(p-S)AP]
    Isotype
    IgG
    Top Product
    Discover our top product MAPK7 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Zhuang, Zhang, Xiong, Wang, Luo, Han, Meng, Zhang, Liao, Liu: "CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5-AP-1 axis." dans: Cell death & disease, Vol. 7, Issue 10, pp. e2415, (2017) (PubMed).

  • Antigène
    MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))
    Autre désignation
    ERK5 (MAPK7 Produits)
    Synonymes
    anticorps BMK1, anticorps ERK4, anticorps ERK5, anticorps PRKM7, anticorps Erk5-T, anticorps ATMPK7, anticorps F8D23.5, anticorps F8D23_5, anticorps MAP kinase 7, anticorps Bmk1, anticorps Erk5, anticorps Prkm7, anticorps ERK-5, anticorps bmk1, anticorps erk4, anticorps mapk7, anticorps prkm7, anticorps mitogen-activated protein kinase 7, anticorps MAP kinase 7, anticorps mitogen-activated protein kinase 7 L homeolog, anticorps MAPK7, anticorps Mapk7, anticorps MPK7, anticorps mapk7.L
    Sujet

    Synonyms: BMK1, ERK4, ERK5, PRKM7, Mitogen-activated protein kinase 7, MAP kinase 7, MAPK 7, Big MAP kinase 1, BMK-1, Extracellular signal-regulated kinase 5, ERK-5, MAPK7

    Background: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

    ID gène
    5598
    UniProt
    Q13164
    Pathways
    Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling
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