MST1R anticorps (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase)) (AA 1220-1260)

Details for Product anti-MST1R Antibody No. ABIN710336
Antigène
  • CD136
  • CDw136
  • PTK8
  • RON
  • Fv-2
  • Fv2
  • Ron
  • STK
  • Cdw136
  • Ptk8
  • Stk
  • macrophage stimulating 1 receptor
  • macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
  • MST1R
  • Mst1r
Épitope
AA 1220-1260, pTyr1238
29
21
18
17
16
16
15
15
14
7
6
4
4
2
2
2
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
191
68
35
1
1
1
1
Hôte
Lapin
191
20
4
Clonalité
Polyclonal
Conjugué
Cet anticorp MST1R est non-conjugé
13
10
10
10
8
8
5
5
5
5
5
5
2
2
2
2
2
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
111
102
39
39
27
5
5
4
4
3
1
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human MST1R around the phosphorylation site of Tyr1238
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others MST1R products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Ron (MST1R Antibody Extrait)
Sujet

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Subcellular location: Cytoplasm

Synonyms: RON, PTK8, CD136, CDw136, Macrophage-stimulating protein receptor, MSP receptor, Protein-tyrosine kinase 8, p185-Ron, MST1R

ID gène 4486
UniProt Q04912
Pathways Signalisation RTK
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
Images (Fournisseur)
Image no. 1 for anti-Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) (AA 1220-1260), (pTyr1238) antibody (ABIN710336) Antigen: 0.2ug/100ul, Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16...
Image no. 2 for anti-Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) (AA 1220-1260), (pTyr1238) antibody (ABIN710336) Antigen: 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:...
Image no. 3 for anti-Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) (AA 1220-1260), (pTyr1238) antibody (ABIN710336) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti phospho-Ron/M...
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