MAP2K2 anticorps (Mitogen-Activated Protein Kinase Kinase 2) (pSer226)

Details for Product anti-MAP2K2 Antibody No. ABIN710456
Antigène
  • CFC4
  • MAPKK2
  • MEK2
  • MKK2
  • PRKMK2
  • AA589381
  • MK2
  • Prkmk2
  • ATMKK2
  • F27B13.50
  • F27B13_50
  • MAP KINASE KINASE 1
  • MAP kinase kinase 2
  • MK1
  • zgc:172250
  • mitogen-activated protein kinase kinase 2
  • mitogen activated protein kinase kinase 2
  • MAP kinase kinase 2
  • mitogen-activated protein kinase kinase 2b
  • MAP2K2
  • Map2k2
  • MKK2
  • map2k2b
Épitope
pSer226
39
24
19
17
15
14
12
10
10
9
9
7
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
320
184
148
11
9
4
3
2
1
Hôte
Lapin
253
61
7
1
Clonalité
Polyclonal
Conjugué
Cet anticorp MAP2K2 est non-conjugé
20
15
14
7
7
7
7
7
7
7
7
7
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
249
116
112
42
40
35
26
20
16
15
8
6
5
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human MEK2 around the phosphorylation site of Ser226
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others MAP2K2 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Mek2 (MAP2K2 Antibody Extrait)
Sujet

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008].

Synonyms: MAP2K2phospho S226, Cardiofaciocutaneous syndrome, CFC syndrome, Dual specicity mitogen activated protein kinase kinase 2, Dual specicity mitogen-activated protein kinase kinase 2, ERK activator kinase 2, FLJ26075, MAP kinase kinase 2, MAP2K 2, map2k2, MAPK / ERK kinase 2, MAPK/ERK kinase 2, MAPKK 2, MAPKK2, MEK 2, MEK2, Microtubule Associated Protein Kinase Kinase 2, Mitogen activated protein kinase kinase 2, Mitogen activated protein kinase kinase 2 p45, MKK 2, MKK2, MP2K2_HUMAN, OTTHUMP00000165826, OTTHUMP00000165827, PRKMK 2, PRKMK2 V.

ID gène 5605
Pathways Signalisation MAPK, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
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