MAPKAP Kinase 5 anticorps (Mitogen-Activated Protein Kinase-Activated Protein Kinase 5) (AA 160-210)

Details for Product anti-MAPKAPK5 Antibody No. ABIN710546
Antigène
  • MAPKAPK5
  • MK5
  • PRAK
  • MAPKAP-K5
  • MK-5
  • mitogen-activated protein kinase-activated protein kinase 5
  • MAP kinase-activated protein kinase 5
  • MAPKAPK5
  • mapkapk5
  • Mapkapk5
Épitope
AA 160-210, pThr182
35
20
19
18
14
10
8
4
4
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris
180
84
6
1
1
1
1
1
Hôte
Lapin
136
42
8
Clonalité
Polyclonal
Conjugué
Cet anticorp MAPKAP Kinase 5 est non-conjugé
10
7
7
5
5
5
4
4
4
4
4
4
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
146
92
50
17
13
11
7
7
3
2
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human MAPKAPK5 around the phosphorylation site of Thr182
Isotype IgG
Specificité This phosphorylation site is homologous to that of Thr182 in Mouse.
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others MAPKAP Kinase 5 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Mapkapk5 (MAPKAPK5 Antibody Extrait)
Sujet

Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.

Subcellular location: Cytoplasm, Nucleus

Synonyms: MK5, MK-5, PRAK, MAPKAP-K5, MAP kinase-activated protein kinase 5, MAPK-activated protein kinase 5, MAPKAP kinase 5, MAPKAPK-5, p38-regulated/activated protein kinase, MAPKAPK5

ID gène 8550
UniProt Q8IW41
Pathways Signalisation MAPK
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
Images (Fournisseur)
Image no. 1 for anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 160-210), (pThr182) antibody (ABIN710546) Antigen: 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:...
Image no. 2 for anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 160-210), (pThr182) antibody (ABIN710546) Lane 1: mouse lung lysates Lane 2: mouse brain lysates probed with Anti phospho-MAPKA...
Image no. 3 for anti-Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (AA 160-210), (pThr182) antibody (ABIN710546) Formalin-fixed and paraffin embedded rat brain labeled with Anti-phospho-MAPKAPK5(Thr...
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