NFKB1 anticorps (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1) (pSer903) (Cy5)

Details for Product anti-NFKB1 Antibody No. ABIN710610
Antigène
  • EBP-1
  • KBF1
  • NF-kB1
  • NF-kappa-B
  • NF-kappaB
  • NFKB-p105
  • NFKB-p50
  • NFkappaB
  • p105
  • p50
  • NF-kB
  • NF-KB1
  • ebp-1
  • kbf1
  • nf-kappa-b
  • nf-kappaB
  • nfkb-p105
  • nfkb-p50
  • NF-kappaB1
  • p50/p105
  • BICDR-1
  • bicdr1
  • ccdc64
  • nuclear factor kappa B subunit 1
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 L homeolog
  • nuclear factor NF-kappa-B p105 subunit
  • nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • NFKB1
  • Nfkb1
  • nfkb1.L
  • CpipJ_CPIJ012236
  • nfkb1
Épitope
pSer903
54
50
50
33
32
31
23
15
15
9
7
7
7
7
6
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
604
275
236
24
21
18
16
5
5
4
3
2
1
1
1
Hôte
Lapin
568
55
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp NFKB1 est conjugé à/à la Cy5
27
19
19
19
19
19
18
12
9
4
4
4
4
4
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
466
274
201
122
111
60
52
33
19
16
9
5
4
4
3
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human NF KappaB p105 around the phosphorylation site of Ser903 [AH(p-S)LP]
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others NFKB1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Nfkb1 (NFKB1 Antibody Extrait)
Sujet

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. SUBUNIT: Active NF-kappa-B is a heterodimer of an about 50 kDa DNA-binding subunit and the weak DNA-binding subunit p65. Two heterodimers might form a labile tetramer. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI, this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL.

Synonyms: DKFZp686C01211, DNA binding factor KBF1, DNA binding factor KBF1 EBP1, DNA binding factor KBF1 EBP1, DNA-binding factor KBF1, EBP 1, EBP-1, EBP1, KBF1, MGC54151, NF kappa B, NF kappabeta, NF kB1, NFKB 1, NFKB p105, NFKB p50, NFKB1, NFKB1_HUMAN, Nuclear factor kappa B DNA binding subunit, Nuclear factor NF kappa B p105 subunit, Nuclear factor NF kappa B p50 subunit, Nuclear factor NF-kappa-B p50 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p84/NF-kappa-B1 p98.

ID gène 4790
Pathways Signalisation p53, Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades
Indications d'application IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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