NFKBIA anticorps (pTyr305)

N° du produit ABIN710696

Détail du produit anti-NFKBIA anticorps

Antigène: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Épitope: pTyr305

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFKBIA est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human IKB alpha around the phosphorylation site of Tyr305

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-NFKBIA (ABIN710696)

Tian, Wu, Guo, Ma, Huang, Zhao: "Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2." dans: International journal of molecular medicine, Vol. 39, Issue 4, pp. 869-878, (2017) (PubMed).

Liu, Zhang, Han, Wang, Liu, Zhang, Zhou, Xiang: "Inhibition of BTK protects lungs from trauma-hemorrhagic shock-induced injury in rats." dans: Molecular medicine reports, Vol. 16, Issue 1, pp. 192-200, (2017) (PubMed).

Zhao, Zheng, Hu, Shen, Li: "Betulin attenuates kidney injury in septic rats through inhibiting TLR4/NF-κB signaling pathway." dans: Life sciences, Vol. 144, pp. 185-93, (2016) (PubMed).

Li, Zhang, Qi, Zhang, Yi, Li, Zhang: "Valproate ameliorates nitroglycerin-induced migraine in trigeminal nucleus caudalis in rats through inhibition of NF-кB." dans: The journal of headache and pain, Vol. 17, pp. 49, (2016) (PubMed).

Gao, Guo, Wang, Lin, Yu, Sheng, Wu, Gong: "Indirubin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice through the inhibition of inflammation and the induction of Foxp3-expressing regulatory T cells." dans: Acta histochemica, Vol. 118, Issue 6, pp. 606-14, (2016) (PubMed).

Yu, Shi, Qi, Zhao, Gao, Li: "Gypenoside Protects Cardiomyocytes against Ischemia-Reperfusion Injury via the Inhibition of Mitogen-Activated Protein Kinase Mediated Nuclear Factor Kappa B Pathway In Vitro and In Vivo." dans: Frontiers in pharmacology, Vol. 7, pp. 148, (2016) (PubMed).

Zhao, Yang, Zhao, Zhang, Liu: "Fascin Overexpression Promotes Cholangiocarcinoma RBE Cell Proliferation, Migration, and Invasion." dans: Technology in cancer research & treatment, Vol. 15, Issue 2, pp. 322-33, (2016) (PubMed).

Zhang, Ma, Zhang, Dai, Chang, Huang, Tian: "Hyperbaric Oxygen and Ginkgo Biloba Extract Ameliorate Cognitive and Memory Impairment via Nuclear Factor Kappa-B Pathway in Rat Model of Alzheimer's Disease." dans: Chinese medical journal, Vol. 128, Issue 22, pp. 3088-93, (2016) (PubMed).

Chen, Zhang, Ma, Huang, Shao, Wu, Wang: "Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction." dans: PLoS ONE, Vol. 10, Issue 11, pp. e0143868, (2016) (PubMed).

Yan, Wu, Li, Meng, Dai, Zheng, Fu: "Cyanidin-3-O-glucoside Induces Apoptosis and Inhibits Migration of Tumor Necrosis Factor-?-Treated Rat Aortic Smooth Muscle Cells." dans: Cardiovascular toxicology, (2015) (PubMed).

Détails sur NFKBIA

Antigène: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Autre désignation: NFKBIA (NFKBIA Produits)

Synonymes: anticorps IKBA, anticorps MAD-3, anticorps NFKBI, anticorps AI462015, anticorps Nfkbi, anticorps RL/IF-1, anticorps ECI-6/IKBA, anticorps NFKBIA, anticorps ikbaB, anticorps wu:fb81f08, anticorps zgc:56666, anticorps zgc:77616, anticorps ikbaA, anticorps wu:fj16a07, anticorps zgc:85769, anticorps NFKB inhibitor alpha, anticorps nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha, anticorps nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b, anticorps nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a, anticorps NFKBIA, anticorps Nfkbia, anticorps nfkbiab, anticorps nfkbiaa

Sujet:

Synonyms: IKBA, MAD-3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major histocompatibility complex enhancer-binding protein MAD3, NFKBIA, MAD3

Background: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

ID gène: 4792

UniProt: P25963

Pathways: Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling