NFKBIA anticorps (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha) (AA 295-310) (Cy3)

Details for Product anti-NFKBIA Antibody No. ABIN710699
Antigène
  • IKBA
  • MAD-3
  • NFKBI
  • AI462015
  • Nfkbi
  • RL/IF-1
  • ECI-6/IKBA
  • ikbaA
  • wu:fj16a07
  • zgc:85769
  • NFKB inhibitor alpha
  • nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
  • NFKBIA
  • Nfkbia
  • nfkbiaa
Épitope
AA 295-310, pTyr305
63
55
40
35
34
18
17
15
14
12
10
10
8
7
7
5
5
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
485
307
247
31
24
20
19
9
2
2
2
1
1
Hôte
Lapin
429
62
7
7
Clonalité
Polyclonal
Conjugué
Cet anticorp NFKBIA est conjugé à/à la Cy3
26
13
13
13
13
13
12
12
10
6
6
6
3
3
3
3
3
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
364
182
159
78
77
62
40
28
19
17
16
4
4
3
3
3
1
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human IKB alpha around the phosphorylation site of Tyr305
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others NFKBIA products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Nfkbia (NFKBIA Antibody Extrait)
Sujet

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Subcellular location: Cytoplasm, Nucleus

Synonyms: IKBA, MAD-3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major histocompatibility complex enhancer-binding protein MAD3, NFKBIA, MAD3

ID gène 4792
UniProt P25963
Pathways Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades
Indications d'application IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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