NFAT1 anticorps (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2) (pSer330) (HRP)

Details for Product anti-NFAT1 Antibody No. ABIN710720
Antigène
  • NFATC2
  • AI607462
  • NF-ATc2
  • NFAT1
  • NFAT1-D
  • Nfatp
  • NFATP
  • nuclear factor of activated T-cells 2
  • nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
  • NFATC2
  • nfatc2
  • Nfatc2
Épitope
pSer330
33
24
7
6
5
4
3
2
2
2
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
149
83
63
8
7
6
6
5
5
3
1
1
1
Hôte
Lapin
135
11
7
Clonalité
Polyclonal
Conjugué
Cet anticorp NFAT1 est conjugé à/à la HRP
9
6
6
6
6
6
6
6
5
3
3
3
3
3
3
3
3
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
76
47
39
19
18
14
10
6
4
3
2
1
1
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human NFATc2 around the phosphorylation site of Ser330
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others NFAT1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Nfatc2 (NFAT1 Antibody Extrait)
Sujet

Nuclear factor of activated T cells (NFAT) is a family of transcription factors implicated in multiple biological processes including cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. NFAT1 (also known as NFATc2 or NFATp) is a member of this family that is regulated by the calcium-dependent phosphatase calcineurin. When calcineurin is activated by calcium it dephosphorylates multiple residues in the regulatory domain of NFAT1, leading to its translocation to the nucleus and activation of its transcriptional activity. Once in the nucleus, NFAT proteins act synergistically with the AP-1 transcription factor complex to regulate the expression of multiple genes. Serine 54 in mouse NFAT1 has been shown to be important in the regulation of its transcriptional activity.

Synonyms: NFATC2phospho S330, AI607462, KIAA0611, NF ATp, NF-ATc2, NFAT 1, NFAT pre existing subunit, NFAT transcription complex, preexisting component, NFAT1, NFAT1-D, NFATc2, NFATp, Nuclear factor of activated T cells cytoplasmic 2, Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2, Nuclear factor of activated T cells pre-existing component, T cell transcription factor NFAT.

ID gène 4773
Pathways Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, VEGF Signaling
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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