DACT1 anticorps (AA 410-525) (HRP)

N° du produit ABIN7149491

Détail du produit anti-DACT1 anticorps (HRP)

Antigène: DACT1 (Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1))

Épitope: AA 410-525

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DACT1 est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Dapper homolog 1 protein (410-525AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DACT1

Antigène: DACT1 (Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1))

Autre désignation: DACT1 (DACT1 Produits)

Synonymes: anticorps XDpr, anticorps dpr1, anticorps frodo, anticorps hdpr1, anticorps Dapper, anticorps thyex3, anticorps dapper1, anticorps MGC89695, anticorps frd1, anticorps frodo1, anticorps 4921528D17Rik, anticorps AI115603, anticorps DAPPER, anticorps DAPPER1, anticorps FRODO, anticorps Frd1, anticorps Frodo1, anticorps MDpr1, anticorps MTNG3, anticorps THYEX3, anticorps DPR1, anticorps HDPR1, anticorps DACT1, anticorps RGD1564008, anticorps XDpr1a, anticorps dact1, anticorps dpr, anticorps XDpr1b, anticorps dishevelled-binding antagonist of beta-catenin 1, anticorps dishevelled binding antagonist of beta catenin 1, anticorps dishevelled-binding antagonist of beta-catenin 1 L homeolog, anticorps dishevelled-binding antagonist of beta-catenin 1 S homeolog, anticorps dact1, anticorps Dact1, anticorps DACT1, anticorps dact1.L, anticorps dact1.S

Sujet:

Background: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism, the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2, the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.

Aliases: Dact antibody, dact1 antibody, DACT1_HUMAN antibody, Dapper antagonist of beta catenin homolog 1 antibody, Dapper antagonist of catenin 1 antibody, Dapper antibody, Dapper homolog 1 antibody, DAPPER1 antibody, Dpr antibody, Dpr1 antibody, Frd antibody, Frodo antibody, hDPR1 antibody, Hepatocellular carcinoma novel gene 3 protein antibody, Heptacellular carcinoma novel gene 3 antibody, HNG3 antibody, MTNG3 antibody, Thyex3 antibody

UniProt: Q9NYF0

Pathways: Positive Regulation of fat Cell Differentiation