APOBEC3C anticorps (AA 1-190)

N° du produit ABIN7150150

Détail du produit anti-APOBEC3C anticorps

Antigène: APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))

Épitope: AA 1-190

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APOBEC3C est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human DNA dC->dU-editing enzyme APOBEC-3C protein (1-190AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur APOBEC3C

Antigène: APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))

Autre désignation: APOBEC3C (APOBEC3C Produits)

Synonymes: anticorps APOBEC3C, anticorps A3C, anticorps APOBEC1L, anticorps ARDC2, anticorps ARDC4, anticorps ARP5, anticorps PBI, anticorps bK150C2.3, anticorps apolipoprotein B mRNA editing enzyme catalytic subunit 3C, anticorps apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C, anticorps APOBEC3C

Sujet:

Background: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Aliases: A3C antibody, ABC3C_HUMAN antibody, APOBEC1 like antibody, APOBEC1-like antibody, APOBEC1L antibody, APOBEC3C antibody, Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C antibody, ARDC2 antibody, ARDC4 antibody, ARP5 antibody, bK150C2.3 antibody, DNA dC >dU editing enzyme APOBEC 3C antibody, MGC19485 antibody, PBI antibody, Phorbolin I antibody, Phorbolin I protein antibody, Probable DNA dC dU editing enzyme APOBEC 3C antibody, Probable DNA dC->dU-editing enzyme APOBEC-3C antibody

UniProt: Q9NRW3