PDGFRA anticorps (Platelet-Derived Growth Factor Receptor, alpha Polypeptide) (pTyr988) (Biotin)

Details for Product anti-PDGFRA Antibody No. ABIN710953
Antigène
  • AI115593
  • CD140a
  • Pdgfr-2
  • APDGFR
  • PDGFACE
  • CD140A
  • PDGFR-2
  • PDGFR2
  • RHEPDGFRA
  • PDGFR
  • PDGFR-A
  • platelet derived growth factor receptor alpha
  • platelet derived growth factor receptor, alpha polypeptide
  • platelet-derived growth factor receptor, alpha polypeptide L homeolog
  • platelet-derived growth factor receptor, alpha polypeptide
  • PDGFRA
  • Pdgfra
  • pdgfra.L
Épitope
pTyr988
37
29
28
26
19
19
17
16
15
15
15
14
13
11
11
11
11
10
9
9
7
7
6
6
5
5
4
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
502
292
244
6
6
6
5
5
3
3
3
2
2
1
1
1
1
Hôte
Lapin
435
92
5
1
1
Clonalité
Polyclonal
Conjugué
Cet anticorp PDGFRA est conjugé à/à la Biotin
35
26
25
24
23
14
12
12
12
12
12
12
5
5
5
5
5
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
324
216
171
87
69
66
40
31
14
14
12
9
4
3
3
2
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human PDGFRA around the phosphorylation site of Tyr988 [NA(p-Y)IG]
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others PDGFRA products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Pdgfra (PDGFRA Antibody Extrait)
Sujet

The PDGF Receptor Type A (Alpha platelet-derived growth factor receptor precursor, CD140a antigen), a 170kD protein, binds all three isoforms of PDGF with high affinity whereas the PDGF Receptor Type B, a 190kD protein, appears to bind only the PDGF BB homodimer with high affinity. Both receptors are transmembranous, ligand activated protein tyrosine kinases, which phosphorylate a number of important signal transduction proteins, which are bound with differential affinities via SH2 domains. The response of any given cell to PDGF will depend on the types of receptors displayed on the surface and isoforms of PDGF present in the extracellular environment.

Synonyms: PDGFRAphospho Y988, PDGF Receptor alphaTyr849/PDGF Receptor beta Tyr857, Plateletâ€"dirived growth factor receptor-alpha, Alpha platelet derived growth factor receptor, CD 140a, CD140a, CD140a antigen, MGC74795, PDGF alpha chain, PDGF R alpha, PDGFR 2, PDGFR A, PDGFR alpha, PDGFR2, PDGFRA, Platelet derived growth factor receptor 2, Platelet derived growth factor receptor alpha, Platelet derived growth factor receptor alpha polypeptide, PGFRA_HUMAN.

ID gène 5156
Pathways Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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