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IGF2BP1 anticorps (AA 440-534)

IGF2BP1 Reactivité: Humain WB, IHC, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7156356
  • Antigène Voir toutes IGF2BP1 Anticorps
    IGF2BP1 (Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1))
    Épitope
    • 15
    • 10
    • 8
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 440-534
    Reactivité
    • 52
    • 28
    • 27
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Humain
    Hôte
    • 51
    • 1
    Lapin
    Clonalité
    • 51
    • 1
    Polyclonal
    Conjugué
    • 24
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IGF2BP1 est non-conjugé
    Application
    • 32
    • 23
    • 23
    • 13
    • 13
    • 13
    • 8
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 1 protein (440-534AA)
    Isotype
    IgG
    Top Product
    Discover our top product IGF2BP1 Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    IGF2BP1 (Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1))
    Autre désignation
    IGF2BP1 (IGF2BP1 Produits)
    Synonymes
    anticorps IGF2BP1, anticorps ZBP1, anticorps CRD-BP, anticorps CRDBP, anticorps IMP-1, anticorps IMP1, anticorps VICKZ1, anticorps AL024068, anticorps AW549074, anticorps Crdbp, anticorps D030026A21Rik, anticorps D11Moh40e, anticorps D11Moh45, anticorps Neilsen, anticorps Zbp1, anticorps Imp1, anticorps wu:fi72a06, anticorps zgc:152963, anticorps insulin like growth factor 2 mRNA binding protein 1, anticorps insulin-like growth factor 2 mRNA binding protein 1, anticorps IGF2BP1, anticorps Igf2bp1, anticorps igf2bp1
    Sujet

    Background: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript \\\'caging\\\' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3\\\'-UTR, known as the \\\'zipcode\\\'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3\\\'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3\\\'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3\\\'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5\\\'-UTR and 3\\\'-UTR and specifically enhances translation at the HCV IRES, but not 5\\\'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts.

    Aliases: Coding region determinant-binding protein antibody, CRD BP antibody, CRD-BP antibody, CRDBP antibody, IF2B1 antibody, IF2B1_HUMAN antibody, IGF II mRNA binding protein 1 antibody, IGF-II mRNA-binding protein 1 antibody, IGF2 mRNA binding protein 1 antibody, IGF2 mRNA-binding protein 1 antibody, IGF2BP1 antibody, IMP 1 antibody, IMP-1 antibody, IMP1 antibody, Insulin like growth factor 2 mRNA binding protein 1 antibody, Insulin-like growth factor 2 mRNA-binding protein 1 antibody, VICKZ family member 1 antibody, VICKZ1 antibody, ZBP 1 antibody, ZBP-1 antibody, ZBP1 antibody, Zip code binding protein 1 antibody, Zip code-binding protein 1 antibody, Zipcode binding protein 1 antibody, Zipcode-binding protein 1 antibody

    UniProt
    Q9NZI8
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