ABCB4 anticorps (AA 530-693)

N° du produit ABIN7163123

Détail du produit anti-ABCB4 anticorps

Antigène: ABCB4 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4))

Épitope: AA 530-693

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABCB4 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Phosphatidylcholine translocator ABCB4 protein (530-693AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ABCB4

Antigène: ABCB4 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4))

Autre désignation: ABCB4 (ABCB4 Produits)

Synonymes: anticorps ABC21, anticorps GBD1, anticorps ICP3, anticorps MDR2, anticorps MDR2/3, anticorps MDR3, anticorps PFIC-3, anticorps PGY3, anticorps zgc:172149, anticorps Mdr2, anticorps Pgy-2, anticorps Pgy2, anticorps mdr-2, anticorps Pgy3, anticorps ABCB4a, anticorps DEFB1, anticorps PGP2, anticorps PGY2, anticorps PGP3, anticorps ABCB4, anticorps RUNDC3B, anticorps ATP binding cassette subfamily B member 4, anticorps ATP-binding cassette, sub-family B (MDR/TAP), member 4, anticorps beta-defensin 1-like, anticorps ATP-binding cassette, sub-family B (MDR/TAP), member 1B, anticorps RUN domain-containing protein 3B, anticorps ABCB4, anticorps abcb4, anticorps Abcb4, anticorps LOC100861170, anticorps Abcb1b, anticorps LOC101122517

Sujet:

Background: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity).

Aliases: ABC 21 antibody, ABC B4 antibody, ABC21 antibody, ABCB 4 antibody, Abcb4 antibody, ABCB4 protein antibody, ATP binding cassette sub family B MDR/TAP member 4 antibody, ATP binding cassette sub family B member 4 antibody, ATP-binding cassette sub-family B member 4 antibody, GBD1 antibody, ICP3 antibody, MDR 3 antibody, MDR2 antibody, MDR2/3 antibody, MDR3 antibody, MDR3 P glycoprotein antibody, MDR3 P gp antibody, MDR3_HUMAN antibody, Multidrug resistance protein 3 antibody, Multiple drug resistance 3 antibody, P glycoprotein 3 antibody, P-glycoprotein 3 antibody, PFIC 3 antibody, PFIC3 antibody, PGY 3 antibody, PGY3 antibody

UniProt: P21439

Pathways: Regulation of Lipid Metabolism by PPARalpha