PIK3CA anticorps (Catalytic Subunit alpha)

N° du produit ABIN7163188

Détail du produit anti-PIK3CA anticorps

Antigène: PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))

Épitope: AA 1-206, Catalytic Subunit alpha

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIK3CA est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform protein (1-206AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PIK3CA

Antigène: PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))

Autre désignation: PIK3CA (PIK3CA Produits)

Synonymes: anticorps CLOVE, anticorps CWS5, anticorps MCAP, anticorps MCM, anticorps MCMTC, anticorps PI3K, anticorps p110-alpha, anticorps C-P3K, anticorps PI3-kinase, anticorps PI3K-alpha, anticorps pi3-k, anticorps pi3k, anticorps AA414921, anticorps C530050K14, anticorps p50alpha, anticorps p55alpha, anticorps p85alpha, anticorps 6330412C24Rik, anticorps caPI3K, anticorps p110, anticorps p110alpha, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, anticorps Phosphoinositide-3-kinase, catalytic, alpha polypeptide, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, anticorps phosphoinositide-3-kinase regulatory subunit 1, anticorps PIK3CA, anticorps GL50803_14855, anticorps pik3ca, anticorps Pik3ca, anticorps Pik3r1

Sujet:

Background: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).

Aliases: 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha antibody, 5-bisphosphate 3-kinase catalytic subunit alpha isoform antibody, caPI3K antibody, CLOVE antibody, CWS5 antibody, MCAP antibody, MCM antibody, MCMTC antibody, MGC142161 antibody, MGC142163 antibody, p110 alpha antibody, p110alpha antibody, Phosphatidylinositol 3 kinase catalytic alpha polypeptide antibody, Phosphatidylinositol 3 kinase catalytic 110 KD alpha antibody, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha antibody, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform antibody, Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha antibody, Phosphatidylinositol-4 antibody, Phosphoinositide 3 kinase catalytic alpha polypeptide antibody, PI 3 Kinase catalytic subunit alpha antibody, PI3 kinase p110 subunit alpha antibody, PI3-kinase subunit alpha antibody, PI3K antibody, PI3K-alpha antibody, PI3KC A antibody, PIK3C A antibody, Pik3ca antibody, PK3CA antibody, PK3CA_HUMAN antibody, PtdIns 3 kinase p110 antibody, PtdIns-3-kinase subunit alpha antibody, PtdIns-3-kinase subunit p110-alpha antibody, Serine/threonine protein kinase PIK3CA antibody

UniProt: P42336

Pathways: Signalisation PI3K-Akt, Signalisation RTK, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, VEGF Signaling