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LATS1 anticorps (AA 1-280) (FITC)

LATS1 Reactivité: Humain Hôte: Lapin Polyclonal FITC
N° du produit ABIN7169061
  • Antigène Voir toutes LATS1 Anticorps
    LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
    Épitope
    • 16
    • 14
    • 9
    • 7
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-280
    Reactivité
    • 61
    • 48
    • 14
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 59
    • 2
    Lapin
    Clonalité
    • 60
    • 1
    Polyclonal
    Conjugué
    • 20
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LATS1 est conjugé à/à la FITC
    Application
    Veuillez nous consulter SVP
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Serine/threonine-protein kinase LATS1 protein (1-280AA)
    Isotype
    IgG
    Top Product
    Discover our top product LATS1 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
    Autre désignation
    LATS1 (LATS1 Produits)
    Synonymes
    anticorps WARTS, anticorps wts, anticorps AW208599, anticorps Lats, anticorps si:dkey-181i3.5, anticorps wu:fc19a11, anticorps zgc:123219, anticorps lats1, anticorps RGD1564085, anticorps warts, anticorps large tumor suppressor kinase 1, anticorps large tumor suppressor, anticorps large tumor suppressor kinase 1 S homeolog, anticorps LATS1, anticorps Lats1, anticorps lats1, anticorps lats1.S
    Sujet

    Background: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.

    Aliases: h-warts antibody, Large tumor suppressor homolog 1 antibody, LATS large tumor suppressor homolog 1 antibody, LATS1 antibody, LATS1_HUMAN antibody, Serine threonine protein kinase LATS1 antibody, Serine/threonine-protein kinase LATS1 antibody, WARTS antibody, WARTS protein kinase antibody, wts antibody

    UniProt
    O95835
    Pathways
    Regulation of Actin Filament Polymerization, Maintenance of Protein Location
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