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PAK1/2/3 anticorps (Thr402, Thr421, Thr423)

PAK1/2/3 Reactivité: Humain IHC, ELISA, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7180065
  • Antigène Voir toutes PAK1/2/3 Anticorps
    PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
    Épitope
    • 13
    • 12
    • 11
    • 11
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Thr402, Thr421, Thr423
    Reactivité
    • 34
    • 27
    • 26
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 35
    Lapin
    Clonalité
    • 33
    • 2
    Polyclonal
    Conjugué
    • 28
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PAK1/2/3 est non-conjugé
    Application
    • 20
    • 19
    • 18
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    Immunogène
    Synthesized non-phosphopeptide derived from Human PAK1/2/3 around the phosphorylation site of threonine 423/402/421 (R-S-T(p)-M-V).
    Isotype
    IgG
  • Indications d'application
    WB:1:500-1:3000, IHC:1:50-1:100,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
    Autre désignation
    PAK1/PAK2/PAK3 (PAK1/2/3 Produits)
    Synonymes
    anticorps X-PAK1, anticorps XPak1, anticorps pak, anticorps pak-1, anticorps pakalpha, anticorps p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog, anticorps p21 (RAC1) activated kinase 1, anticorps pak1.S, anticorps PAK1
    Sujet

    Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

    Bernadett Boda, J. Neurosci., Dec 2004, 24: 10816 - 10825.
    Donna L. McPhie, J. Neurosci., Jul 2003, 23: 6914.
    Jin-Hun Jung, J. Biol. Chem., Dec 2005, 280: 40025 - 40031.
    Guo-Lei Zhou, Mol. Cell. Biol., Nov 2003, 23: 8058 - 8069.

    Aliases: ADRB2 antibody, Alpha PAK antibody, Alpha-PAK antibody, MGC130000 antibody, MGC130001 antibody, p21 activated kinase 1 antibody, p21 protein (Cdc42/Rac) activated kinase 1 antibody, p21-activated kinase 1 antibody, p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related) antibody, p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) antibody, p65 PAK antibody, p65-PAK antibody, P68-PAK antibody, PAK alpha antibody, PAK-1 antibody, Pak1 antibody, PAK1_HUMAN antibody, Paka antibody, PAKalpha antibody, Protein kinase MUK2 antibody, Rac/p21-activated kinase antibody, Serine/threonine-protein kinase PAK 1 antibody, STE20 homolog yeast antibody

    UniProt
    Q13153
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