RPA2 anticorps (Thr21)

N° du produit ABIN7180080

L’anticorps Lapin Polyclonal anti-RPA2 a été validé pour WB, ELISA et IHC. Il convient pour détecter RPA2 dans des échantillons de Humain.

Aperçu rapide pour RPA2 anticorps (Thr21) (ABIN7180080)

Antigène: RPA2 (Replication Protein A2, 32kDa (RPA2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPA2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-RPA2 anticorps

Épitope: Thr21

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human RFA2 around the phosphorylation site of threonine 21 (G-Y-T(p)-Q-S).

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RPA2

Antigène: RPA2 (Replication Protein A2, 32kDa (RPA2))

Autre désignation: RPA2

Sujet:

Background: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage the RPA complex controls DNA repair and DNA damage checkpoint activation. It is required for the recruitment of the DNA double-strand break repair factors RAD52 and RAD51 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP which is involved in replication fork restart to sites of DNA damage. May also play a role in telomere maintenance.

Erdile L.F., J. Biol. Chem. 265:3177-3182(1990).
Gregory S.G., Nature 441:315-321(2006).
Niu H., J. Biol. Chem. 272:12634-12641(1997).
Cho J.M., Nucleic Acids Res. 28:3478-3485(2000)

Aliases: 60S acidic ribosomal protein P1 antibody, AA409079 antibody, AI325195 antibody, AU020965 antibody, ik:tdsubc_2g1 antibody, M(2)21C antibody, MGC137236 antibody, OTTHUMP00000004008 antibody, p32 antibody, p34 antibody, RCJMB04_6d17 replication protein A2, 32 kDa antibody, REPA2 antibody, Replication factor A protein 2 antibody, Replication protein A 32 kDa subunit antibody, Replication protein A 32 kDa subunit antibody, Replication protein A 34 kDa subunit antibody, Replication protein A antibody, Replication Protein A2 (32 kDa) antibody, Replication protein A2 antibody, Replication protein A2, 32 kDa antibody, RF-A protein 2 antibody, Rf-A2 antibody, RFA antibody, RFA2_HUMAN antibody, RP-A p32 antibody, RP-A p34 antibody, RP21C antibody, RPA 2 antibody, RPA 32 antibody, RPA antibody, Rpa2 antibody, RPA32 antibody, RPA34 antibody, RpLP1 antibody, RpP2 antibody, xx:tdsubc_2g1 antibody, zgc:109822 antibody

UniProt: P15927

Pathways: Telomere Maintenance, Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA