Cullin 2 anticorps

N° du produit ABIN7180925

Détail du produit anti-Cullin 2 anticorps

Antigène: Cullin 2 (CUL2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cullin 2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from Human Cullin 2.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Cullin 2

Antigène: Cullin 2 (CUL2)

Autre désignation: CUL2 (CUL2 Produits)

Synonymes: anticorps cul2, anticorps Cullin-2, anticorps fj48a06, anticorps wu:fj48a06, anticorps cullin-2, anticorps LOC100221330, anticorps 1300003D18Rik, anticorps 4932411N15Rik, anticorps AI327301, anticorps mKIAA4106, anticorps ATCUL2, anticorps F22D16.2, anticorps F22D16_2, anticorps cullin 2, anticorps cullin 2, anticorps cullin-2, anticorps putative cullin-2 (cul-2), anticorps cullin 2 L homeolog, anticorps Cullin-2, anticorps cul2, anticorps CUL2, anticorps PTRG_05231, anticorps Smp_079740, anticorps LOC100550749, anticorps Cul2, anticorps cul2.L, anticorps cul-2

Sujet:

Background: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

Seiji Shiraishi, J. Biol. Chem., Mar 2007, 282: 9017 - 9028.
Isabelle Groulx, J. Biol. Chem., Mar 2000, 275: 8991.
Dimitris Liakopoulos, PNAS, May 1999, 96: 5510.
Kyungwon Huh, AACR Meeting Abstracts, Apr 2006, 2006: 1326.

Aliases: Cul2 antibody, CUL 2 antibody, CUL-2 antibody, CUL2 antibody, CUL2_HUMAN antibody, cullin 2 antibody, cullin homolog 2 antibody, Cullin-2 antibody, MGC131970 antibody

UniProt: Q13617

Pathways: M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interactome