Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

SH3KBP1 anticorps (AA 591-665)

SH3KBP1 Reactivité: Humain WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN716216
  • Antigène Voir toutes SH3KBP1 Anticorps
    SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))
    Épitope
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 591-665
    Reactivité
    • 27
    • 10
    • 9
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 23
    • 5
    Lapin
    Clonalité
    • 24
    • 4
    Polyclonal
    Conjugué
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SH3KBP1 est non-conjugé
    Application
    • 26
    • 13
    • 13
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Cow,Sheep,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human SH3KBP1
    Isotype
    IgG
    Top Product
    Discover our top product SH3KBP1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))
    Autre désignation
    Sh3kbp1 (SH3KBP1 Produits)
    Synonymes
    anticorps CD2BP3, anticorps CIN85, anticorps GIG10, anticorps HSB-1, anticorps HSB1, anticorps MIG18, anticorps 1200007H22Rik, anticorps 1700125L08Rik, anticorps 5830464D22Rik, anticorps AI447724, anticorps IN85, anticorps Ruk, anticorps Seta, anticorps SH3 domain containing kinase binding protein 1, anticorps SH3-domain kinase binding protein 1, anticorps SH3 domain-containing kinase-binding protein 1, anticorps SH3KBP1, anticorps sh3kbp1, anticorps LOC100551401, anticorps Sh3kbp1
    Sujet

    Synonyms: Cbl interacting protein, Cbl interacting protein of 85 kDa, CD2 binding protein 3, CD2BP3, CIN 85, CIN85, GIG 10, GIG10, HSB 1, Human Src family kinase binding protein 1, MIG 18, MIG18, Migration inducing gene 18 protein, SH3 domain kinase binding protein 1, SH3BP 1, Src family kinase binding protein 1, src related kinase binding protein 1, SH3K1_HUMAN.

    Background: SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.

    ID gène
    30011
    Pathways
    EGFR Signaling Pathway, EGFR Downregulation
Vous êtes ici:
Support technique