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LRP8 anticorps (AA 851-963)

LRP8 Reactivité: Humain, Souris, Rat, Poulet WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN719426
  • Antigène Voir toutes LRP8 Anticorps
    LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))
    Épitope
    • 14
    • 9
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 851-963
    Reactivité
    • 49
    • 22
    • 19
    • 16
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Poulet
    Hôte
    • 46
    • 4
    Lapin
    Clonalité
    • 45
    • 5
    Polyclonal
    Conjugué
    • 24
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LRP8 est non-conjugé
    Application
    • 46
    • 24
    • 15
    • 12
    • 12
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    This antibody will detect both the membrane bound and the secreted isoform variants of this protein.
     Réactivité croisée
    Poulet, Humain, Souris, Rat
    Homologie
    Dog,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human ApoER2
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))
    Autre désignation
    ApoER2 (LRP8 Produits)
    Synonymes
    anticorps LRP8, anticorps APOER2, anticorps HSZ75190, anticorps LRP-8, anticorps MCI1, anticorps 4932703M08Rik, anticorps AA921429, anticorps AI848122, anticorps ApoER2, anticorps Lr8b, anticorps LR8B, anticorps LDL receptor related protein 8, anticorps low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, anticorps LRP8, anticorps Lrp8
    Sujet

    Synonyms: MCI1, LRP-8, APOER2, HSZ75190, Low-density lipoprotein receptor-related protein 8, Apolipoprotein E receptor 2, LRP8

    Background: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.

    ID gène
    7804
    UniProt
    Q14114
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