TGFBR2 anticorps (AA 241-330)

N° du produit ABIN725225

Détail du produit anti-TGFBR2 anticorps

Antigène: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Épitope: AA 241-330

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TGFBR2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Boeuf (Vache), Humain, Souris, Lapin, Rat

Homologie: Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TGF beta R2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-TGFBR2 (ABIN725225)

Friedrichs, Fink, Mauch, Kindler, Hartmann, Schüle, Buettner, Friedrichs: "TGF-?1-dependent induction and nuclear translocation of FHL2 promotes keratin expression in pilomatricoma." dans: Virchows Archiv : an international journal of pathology, Vol. 466, Issue 2, pp. 199-208, (2015) (PubMed).

Hirayama, Koyama, Sawai, Fujii, Naito, Fukuda, Kageyama: "Localization of TGF-? and TGF-? receptor in bovine term placentome and expression differences between spontaneous and induced parturition." dans: Placenta, Vol. 36, Issue 11, pp. 1239-45, (2015) (PubMed).

Abdelmagid, Belcher, Moussa, Lababidi, Sondag, Novak, Sanyurah, Frara, Razmpour, Del Carpio-Cano, Safadi: "Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro." dans: The American journal of pathology, Vol. 184, Issue 3, pp. 697-713, (2014) (PubMed).

Li, Li, Pan, Jin: "TNF-α enhances the effect of TGF-β on Gli2 expression in the KG-1 leukemic cell line." dans: Experimental and therapeutic medicine, Vol. 8, Issue 2, pp. 676-680, (2014) (PubMed).

Détails sur TGFBR2

Antigène: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Autre désignation: TGF beta Receptor 2 (TGFBR2 Produits)

Sujet:

Synonyms: AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII, TGF-beta receptor type-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGFBR2

Background: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

ID gène: 7048

UniProt: P37173