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IRS4 anticorps (AA 401-500) (Cy5.5)

IRS4 Reactivité: Souris, Rat IF (cc), IF (p) Hôte: Lapin Polyclonal Cy5.5
N° du produit ABIN726025
  • Antigène Voir toutes IRS4 Anticorps
    IRS4 (Insulin Receptor Substrate 4 (IRS4))
    Épitope
    • 15
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-500
    Reactivité
    • 31
    • 22
    • 14
    Souris, Rat
    Hôte
    • 35
    • 2
    • 1
    Lapin
    Clonalité
    • 36
    • 2
    Polyclonal
    Conjugué
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp IRS4 est conjugé à/à la Cy5.5
    Application
    • 25
    • 25
    • 22
    • 11
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from mouse IRS-4
    Isotype
    IgG
    Top Product
    Discover our top product IRS4 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    IRS4 (Insulin Receptor Substrate 4 (IRS4))
    Autre désignation
    IRS-4 (IRS4 Produits)
    Synonymes
    anticorps IRS4, anticorps irs-4, anticorps py160, anticorps IRS-4, anticorps PY160, anticorps irs2, anticorps irs2-a, anticorps insulin receptor substrate 4, anticorps insulin receptor substrate 4 S homeolog, anticorps IRS4, anticorps irs4, anticorps Irs4, anticorps irs4.S
    Sujet

    Synonyms: Insulin receptor substrate 4, IRS-4, Phosphoprotein of 160 kDa, pp160

    Background: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.

    ID gène
    16370
    UniProt
    Q9Z0Y7
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