CYP3A4 anticorps (AA 18-120)

N° du produit ABIN733793

Détail du produit anti-CYP3A4 anticorps

Antigène: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Épitope: AA 18-120

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP3A4 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: Will detect CYP 3A4, 3A7, 3A5, and 3A9

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CYP3A4

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-CYP3A4 (ABIN733793)

Ito, Otsuki, Zhang, Konno, Kurahashi, Takahashi, Yamato, Matsuoka, Yamada, Miyata, Fujii: "Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice." dans: Life sciences, Vol. 95, Issue 1, pp. 1-8, (2014) (PubMed).

Détails sur CYP3A4

Antigène: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Autre désignation: CYP3A4 (CYP3A4 Produits)

Synonymes: anticorps CP33, anticorps CP34, anticorps CYP3A, anticorps CYP3A3, anticorps CYPIIIA3, anticorps CYPIIIA4, anticorps HLP, anticorps NF-25, anticorps P450C3, anticorps P450PCN1, anticorps MGC108372, anticorps CYP3A80, anticorps CYP3A4, anticorps CYP3A21, anticorps CYPIIIA21, anticorps CYP3A12, anticorps cytochrome P450 family 3 subfamily A member 4, anticorps cytochrome P450 family 3 subfamily A member 43, anticorps cytochrome P450 3A4, anticorps cytochrome P450, subfamily IIIA, polypeptide 4, anticorps cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, anticorps cytochrome P450, family 3, subfamily A, polypeptide 4, anticorps CYP3A4, anticorps CYP3A43, anticorps PTRG_01782, anticorps PTRG_06060, anticorps cyp3a4

Sujet:

Synonyms: Cytochrome p450 3A4, CP33, CP34, CYP3A, CYP3A3, CYP3A4, CYPIIIA4, CYPIIIA3, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Glucocorticoid inducible P450, HLP, MGC126680, NF 25, NF25, P450 III steroid inducible, P450 PCN1, P450C3, P450PCN1, Quinine 3 monooxygenase, Taurochenodeoxycholate 6 alpha hydroxylase, CP3A4_HUMAN, 1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450-PCN1, Nedipine oxidase, Quinine 3-monooxygenase, Taurochenodeoxycholate 6-alpha-hydroxylase, CYP3A4, CYP3A7, CYP3A5, CYP3A9

Background: Cytochromes P450 are a group of heme thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8 oxidation, omeprazole sulphoxidation, midazolam 1 hydroxylation and midazolam 4 hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.

Poids moléculaire: 46kDa

ID gène: 1576

Pathways: Steroid Hormone Biosynthesis