IL6RA anticorps (AA 351-460)

N° du produit ABIN734693

Détail du produit anti-IL6RA anticorps

Antigène: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Épitope: AA 351-460

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL6RA est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse IL-6R alpha

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-IL6RA (ABIN734693)

Urushima, Fujimoto, Mishima, Ohkawara, Honda, Lee, Kawahata, Serada, Naka: "Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells." dans: Arthritis research & therapy, Vol. 19, Issue 1, pp. 137, (2017) (PubMed).

Prystaz, Kaiser, Kovtun, Haffner-Luntzer, Fischer, Rapp, Liedert, Strauss, Waetzig, Rose-John, Ignatius: "Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing." dans: The American journal of pathology, Vol. 188, Issue 2, pp. 474-490, (2017) (PubMed).

Détails sur IL6RA

Antigène: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Autre désignation: IL-6R alpha (IL6RA Produits)

Synonymes: anticorps IL6R1, anticorps Il6ra, anticorps CD126, anticorps IL-6R-1, anticorps IL-6RA, anticorps IL6Q, anticorps IL6RA, anticorps IL6RQ, anticorps gp80, anticorps IL-6R, anticorps Il6r, anticorps interleukin 6 receptor, anticorps interleukin 6 receptor, alpha, anticorps Il6r, anticorps IL6R, anticorps Il6ra

Sujet:

Synonyms: Il6r, CD126, IL-6R, Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, Il6ra

Background: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

ID gène: 16194

UniProt: P22272

Pathways: Signalistation JAK/STAT, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints