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IRF3 anticorps (pSer396)

IRF3 Reactivité: Humain, Souris, Rat, Singe WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN742688
  • Antigène Voir toutes IRF3 Anticorps
    IRF3 (Interferon Regulatory Factor 3 (IRF3))
    Épitope
    • 17
    • 16
    • 15
    • 14
    • 13
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer396
    Reactivité
    • 147
    • 92
    • 56
    • 30
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Singe
    Hôte
    • 154
    • 16
    • 2
    Lapin
    Clonalité
    • 136
    • 36
    Polyclonal
    Conjugué
    • 93
    • 12
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp IRF3 est non-conjugé
    Application
    • 124
    • 68
    • 33
    • 33
    • 28
    • 26
    • 19
    • 11
    • 10
    • 9
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain, Singe, Souris, Rat
    Homologie
    Dog,Cow,Sheep,Pig
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic phosphopeptide derived from human IRF3 around the phosphorylation site of Ser396
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Ando, Matsumoto, Taguchi, Kobayashi: "Poly (I:C) impairs NO donor-induced relaxation by overexposure to NO via the NF-kappa B/iNOS pathway in rat superior mesenteric arteries." dans: Free radical biology & medicine, Vol. 112, pp. 553-566, (2017) (PubMed).

    Le Bel, Gosselin: "Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection." dans: PLoS ONE, Vol. 10, Issue 10, pp. e0139856, (2015) (PubMed).

    Ichikawa, Sugiura, Koarai, Minakata, Kikuchi, Morishita, Oka, Kanai, Kawabata, Hiramatsu, Akamatsu, Hirano, Nakanishi, Matsunaga, Yamamoto, Ichinose: "TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 11, pp. 4977-88, (2014) (PubMed).

    Menasria, Boivin, Lebel, Piret, Gosselin, Boivin: "Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection." dans: Journal of virology, Vol. 87, Issue 13, pp. 7301-8, (2013) (PubMed).

  • Antigène
    IRF3 (Interferon Regulatory Factor 3 (IRF3))
    Autre désignation
    IRF3 (IRF3 Produits)
    Synonymes
    anticorps irf3, anticorps IRF3, anticorps C920001K05Rik, anticorps IRF-3, anticorps interferon regulatory factor 3, anticorps interferon regulatory factor 7, anticorps irf3, anticorps IRF3, anticorps irf-3, anticorps Irf3, anticorps IRF7
    Sujet

    Synonyms: Interferon regulatory factor 3, IRF-3, IRF3

    Background: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

    ID gène
    3661
    UniProt
    Q14653
    Pathways
    Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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