KIT anticorps (Mast/stem Cell Growth Factor Receptor) (AA 700-750)

Details for Product anti-KIT Antibody No. ABIN743393
Antigène
  • C-Kit
  • CD117
  • PBT
  • SCFR
  • Bs
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • c-kit
  • MGF
  • KIT
  • C-KIT
  • kit
  • receptor
  • sparse
  • Xkl-1
  • kit-a
  • kit-b
  • kl1-A
  • krk1
  • pbt
  • scfr
  • KIT proto-oncogene receptor tyrosine kinase
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a
  • KIT proto-oncogene receptor tyrosine kinase S homeolog
  • KIT
  • Kit
  • kita
  • kit
  • kit.S
Épitope
AA 700-750, pTyr721
69
67
65
65
53
46
34
33
32
32
26
25
23
20
18
18
18
18
18
18
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4
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3
3
3
3
2
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2
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2
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2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
1329
464
169
45
44
38
25
19
14
5
4
4
4
3
2
1
1
1
Hôte
Lapin
1049
366
161
14
2
2
Clonalité
Polyclonal
Conjugué
Cet anticorp KIT est non-conjugé
146
133
127
109
86
76
21
16
15
14
14
14
8
8
8
8
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8
6
5
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4
4
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4
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4
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4
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4
3
3
2
2
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
679
625
442
347
212
150
115
104
70
68
55
29
18
13
11
10
5
3
2
2
2
1
1
1
1
Options
Immunogène KLH conjugated synthetic phosphopeptide derived from human c-Kit around the phosphorylation site of Tyr721
Isotype IgG
Specificité This phosphorylation site is homologous to that of Tyr723 in Mouse and Tyr722 in Rat.
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others KIT products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation C-Kit (KIT Antibody Extrait)
Sujet

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

Subcellular location: Cytoplasm

Synonyms: PBT, SCFR, C-Kit, CD117, Mast/stem cell growth factor receptor Kit, Piebald trait protein, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, KIT

ID gène 3815
UniProt P10721
Pathways Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 700-750), (pTyr721) antibody (ABIN743393) Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-Phospho-c-Ki...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 700-750), (pTyr721) antibody (ABIN743393) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti-c-...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 700-750), (pTyr721) antibody (ABIN743393) Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-Phospho-c-Ki...
Produit citée dans: Halsey, Thamm, Weishaar, Burton, Charles, Gustafson, Avery, Ehrhart: "Expression of Phosphorylated KIT in Canine Mast Cell Tumor." dans: Veterinary pathology, Vol. 54, Issue 3, pp. 387-394, 2017 (PubMed). Méthode utilisée: Western Blotting (WB), Western Blotting (WB) (Échantillon (espèces): Dog (Canine)). Détails: Sample: cutaneous mast cell tumor

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