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KAP1 anticorps (pSer824)

TRIM28 Reactivité: Humain WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN746108
  • Antigène Voir toutes KAP1 (TRIM28) Anticorps
    KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
    Épitope
    • 28
    • 15
    • 11
    • 10
    • 8
    • 6
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer824
    Reactivité
    • 114
    • 53
    • 49
    • 10
    • 9
    • 8
    • 7
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 114
    • 16
    • 4
    Lapin
    Clonalité
    • 107
    • 27
    Polyclonal
    Conjugué
    • 63
    • 10
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp KAP1 est non-conjugé
    Application
    • 85
    • 42
    • 40
    • 26
    • 25
    • 22
    • 22
    • 20
    • 19
    • 15
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    This phosphorylation site is homologous across the listed species.
     Réactivité croisée
    Humain
    Homologie
    Mouse,Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic phosphopeptide derived from human TIF1 beta around the phosphorylation site of Ser824
    Isotype
    IgG
    Top Product
    Discover our top product TRIM28 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Ding, Zhang, Wang, Wang, Fan, He, Zhang, Gao, Li, Chen: "γ-H2AX/53BP1/pKAP-1 foci and their linear tracks induced by in vitro exposure to radon and its progeny in human peripheral blood lymphocytes." dans: Scientific reports, Vol. 6, pp. 38295, (2016) (PubMed).

  • Antigène
    KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
    Autre désignation
    T1 beta (TRIM28 Produits)
    Synonymes
    anticorps KAP1, anticorps RNF96, anticorps TF1B, anticorps TIF1B, anticorps TRIM28, anticorps kap1, anticorps rnf96, anticorps tf1b, anticorps tif1b, anticorps AA408787, anticorps KAP-1, anticorps KRIP-1, anticorps Tif1b, anticorps Tif1beta, anticorps Kap1, anticorps Krip1, anticorps TIF1BETA, anticorps tripartite motif containing 28, anticorps tripartite motif containing 28 L homeolog, anticorps tripartite motif-containing 28, anticorps TRIM28, anticorps trim28.L, anticorps Trim28
    Sujet

    Synonyms: KAP1, TF1B, RNF96, TIF1B, PPP1R157, Transcription intermediary factor 1-beta, TIF1-beta, E3 SUMO-protein ligase TRIM28, KRAB-associated protein 1, KAP-1, KRAB-interacting protein 1, KRIP-1, Nuclear corepressor KAP-1, RING finger protein 96, Tripartite motif-containing protein 28, TRIM28

    Background: Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation, the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.

    ID gène
    10155
    UniProt
    Q13263
    Pathways
    Signalisation Hedgehog, Positive Regulation of Response to DNA Damage Stimulus
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