SLC39A1 anticorps (N-Term)

N° du produit ABIN783795

Détail du produit anti-SLC39A1 anticorps

Antigène: SLC39A1 (Solute Carrier Family 39 (Zinc Transporter), Member 1 (SLC39A1))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC39A1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects Zinc transporter ZIP1 / SLC39A1 at N-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogène: 16 amino acid peptide near the amino terminus of human ZIP1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur SLC39A1

Antigène: SLC39A1 (Solute Carrier Family 39 (Zinc Transporter), Member 1 (SLC39A1))

Autre désignation: Zinc Transporter ZIP1 / SLC39A1 (SLC39A1 Produits)

Synonymes: anticorps cb629, anticorps DrZIP1, anticorps sb:cb629, anticorps zgc:111852, anticorps frzip1p, anticorps zip1, anticorps zirtl, anticorps ZIP1, anticorps ZIRTL, anticorps Zip1, anticorps Zirtl, anticorps solute carrier family 39 (zinc transporter), member 1, anticorps solute carrier family 39 member 1, anticorps solute carrier family 39 member 1 L homeolog, anticorps slc39a1, anticorps Slc39a1, anticorps SLC39A1, anticorps slc39a1.L

Sujet: ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappaB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.Synonyms: IRT1, Solute carrier family 39 member 1, ZIP-1, ZIP1, ZIRTL, Zinc-iron-regulated transporter-like, Zrt- and Irt-like protein 1

ID gène: 27173

NCBI Accession: NP_055252

UniProt: Q9NY26

Pathways: Autophagy