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SIRT4 anticorps (AA 51-150)

Name: SIRT4 anticorps (AA 51-150)
SKU: ABIN872709
Price: 414.62 EUR
Availability: InStock

SIRT4 Reactivité: Souris, Rat WB, ELISA, IHC (p) Hôte: Lapin Polyclonal unconjugated

Mouse cerebrum lysates probed with SIRT4 Polyclonal Antibody, unconjugated at 1:300 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 90 minutes at 37°C.

Paraformaldehyde-fixed, paraffin embedded rat stomach tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-SIRT4 Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining

IHC (p)

Paraformaldehyde-fixed, paraffin embedded rat kidney tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-SIRT4 Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining

IHC (p)

Mouse liver lysates probed with SIRT4 Polyclonal Antibody, unconjugated at 1:300 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 90 minutes at 37°C.

4 images

(2 références)

N° du produit ABIN872709

Fiche de données

Antigène Voir toutes SIRT4 Anticorps

SIRT4 (Sirtuin 4 (SIRT4))
Épitope
12

11

8

6

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 51-150
Reactivité
51

34

24

5

4

4

3

3

3

2

1

1

1

1

1

1
Souris, Rat
Hôte
50

8

2

1
Lapin
Anticorps secondaires appropriés
Clonalité
55

6
Polyclonal
Conjugué
30

10

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1
Cet anticorp SIRT4 est non-conjugé
Application
56

26

15

4

4

4

3

2

2

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée

Souris, Rat

Homologie

Human,Cow,Sheep,Pig,Horse,Rabbit,Zebrafish,Drosophila

Purification

Purified by Protein A.

Immunogène

KLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4

Isotype

IgG

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SIRT4 Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated

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SIRT4 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 1C8 unconjugated

anti-Sirtuin 4 (SIRT4) (AA 216-265) antibody
SIRT4 Reactivité: Humain, Chien, Porc, Singe WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated

anti-Sirtuin 4 (SIRT4) (N-Term) antibody
SIRT4 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Porc, Cheval, Lapin, Mouton, Cobaye, Chévre, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated

Indications d'application

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Restrictions

For Research Use only
Format

Liquid

Concentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur

ProClin

Précaution d'utilisation

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock

4 °C,-20 °C

Stockage commentaire

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption

12 months
Takumida, Takumida, Katagiri, Anniko: "Localization of sirtuins (SIRT1-7) in the aged mouse inner ear." dans: Acta oto-laryngologica, pp. 1-12, (2015) (PubMed).

Takumida, Takumida, Anniko: "Localization of sirtuins in the mouse inner ear." dans: Acta oto-laryngologica, Vol. 134, Issue 4, pp. 331-8, (2014) (PubMed).
Antigène

SIRT4 (Sirtuin 4 (SIRT4))

Autre désignation

SIRT4 (SIRT4 Produits)

Synonymes

anticorps SIRT4, anticorps im:7139453, anticorps SIR2L4, anticorps 4930596O17Rik, anticorps sirtuin 4, anticorps SIRT4, anticorps sirt4, anticorps Sirt4

Sujet

Synonyms: SIR2L4, NAD-dependent protein deacetylase sirtuin-4, NAD-dependent ADP-ribosyltransferase sirtuin-4, Regulatory protein SIR2 homolog 4, SIR2-like protein 4, SIRT4
Background: Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.

ID gène

23409

UniProt

Q9Y6E7

Pathways

Negative Regulation of Hormone Secretion