FIP200 anticorps (AA 501-600)

N° du produit ABIN872758

Détail du produit anti-FIP200 anticorps

Antigène: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Épitope: AA 501-600

Reactivité: Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FIP200 est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Poulet

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human RB1CC1

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-FIP200 (ABIN872758)

Xue, Xue, Zhang, Li, Jiang: "miR-130b-3p/301b-3p negatively regulated Rb1cc1 expression on myogenic differentiation of chicken primary myoblasts." dans: Biotechnology letters, Vol. 39, Issue 11, pp. 1611-1619, (2017) (PubMed).

Détails sur FIP200

Antigène: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Autre désignation: Rb1cc1 (RB1CC1 Produits)

Synonymes: anticorps DKFZp459E2330, anticorps CC1, anticorps FIP200, anticorps 2900055E04Rik, anticorps 5930404L04Rik, anticorps Cc1, anticorps LaXp180, anticorps RB1 inducible coiled-coil 1, anticorps RB1 inducible coiled-coil 1 L homeolog, anticorps RB1-inducible coiled-coil 1, anticorps RB1CC1, anticorps rb1cc1.L, anticorps rb1cc1, anticorps Rb1cc1

Sujet:

Synonyms: CC1, ATG17, FIP200, PPP1R131, RB1-inducible coiled-coil protein 1, FAK family kinase-interacting protein of 200 kDa, RB1CC1, KIAA0203, RBICC

Background: Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways.

ID gène: 9821

UniProt: Q8TDY2

Pathways: Regulation of Cell Size, Autophagy