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This gene product belongs to the family of glutathione peroxidase, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq].
Subcellular location: Cytoplasm
Synonyms: Gpx, CGPx, GPx-1, GSHPx-1, AI19524, AL33363, Glutathione peroxidase 1, Cellular glutathione peroxidase, Selenium-dependent glutathione peroxidase 1, Gpx1