Group I mGLUR (AA 681-706) anticorps (Alexa Fluor 488)

Détails pour le produit réf. ABIN899773, Fournisseur: Connectez-vous pour afficher
Antigène
Épitope
AA 681-706
15
Reactivité
Humain, Souris, Rat (Rattus)
15
15
15
Hôte
Lapin
15
Clonalité
Polyclonal
Conjugué
Alexa Fluor 488
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
13
12
3
3
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène KLH conjugated synthetic peptide derived from human GRM1
Isotype IgG
Purification Purified by Protein A.
Antigène
Sujet

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms, some of which may have distinct functions. [provided by RefSeq].

Subcellular location: Cytoplasm

Synonyms: glutamate receptor metabotropic 1, Glutamate Receptor Metabotropic 1,Metabotropic glutamate receptor 1, mGluR1,MGLUR1, GRM1_HUMAN, MGLUR5, mGlur5, GRM5, GRM5_HUMAN.

ID gène 2911, 2915
Indications d'application FCM 1:20-100
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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