Hemagglutinin anticorps (Influenza A Virus H1N1 (A/California/04/2009)) (Alexa Fluor 555)

Détails pour le produit réf. ABIN900022, Fournisseur: Connectez-vous pour afficher
Antigène
  • hemagglutinin
  • Hemagglutinin
  • HA
  • HA
  • ha
Reactivité
Influenza A Virus H1N1
368
315
149
97
51
42
29
26
20
15
13
13
12
7
7
6
6
6
5
5
5
5
4
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Virus Strain
A/California/04/2009
Hôte
Lapin
792
398
25
5
5
1
Clonalité
Polyclonal
Conjugué
Alexa Fluor 555
29
27
26
21
21
14
14
14
14
14
14
14
13
13
7
7
7
7
7
7
7
7
6
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
1011
645
426
387
123
109
101
92
78
45
29
22
21
15
14
9
9
7
7
4
4
4
4
2
2
2
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène KLH conjugated synthetic peptide derived from Influenza A Virus Hemagglutinin (strain swl A/California/04/2009 H1N1)
Isotype IgG
Attributs du produit Antibody is specific for: Influenza A virus H1N1 (strain swl A/California/04/2009 H1N1)
Purification Purified by Protein A.
Antigène
Classe de substances Influenza Protein
Sujet

Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Influenza A Virus (strain swl A/California/04/2009 H1N1)

Subcellular location: Membrane bound

Synonyms: HA, Hemagglutinin, Influenza A Virus (strain swl A/California/04/2009 H1N1)

UniProt C3W5S1
Indications d'application IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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