The antibody MEM-108 reacts with an extracellular epitope of CD98, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain + 45 kDa non-glykosylated light chain). CD98 is expressed on T lymphocytes (upon activation) and activated NK cells, it is also present at low levels on B lymphocytes, NK cells, monocytes and platelets.
anticorps 4F2, anticorps 4F2HC, anticorps 4T2HC, anticorps CD98, anticorps CD98HC, anticorps MDU1, anticorps NACAE, anticorps Mdu1, anticorps MGC53951, anticorps slc3a2, anticorps MGC53965, anticorps SLC3A2, anticorps AI314110, anticorps Cd98, anticorps Ly-10, anticorps Ly-m10, anticorps Ly10, anticorps Mgp-2hc, anticorps fc65h12, anticorps wu:fc65h12, anticorps id:ibd1327, anticorps sb:cb519, anticorps wu:fe14a07, anticorps wu:fq18d12, anticorps zgc:55813, anticorps solute carrier family 3 member 2, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2 L homeolog, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2 S homeolog, anticorps solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2a, anticorps solute carrier family 3 (amino acid transporter heavy chain), member 2b, anticorps SLC3A2, anticorps Slc3a2, anticorps slc3a2.L, anticorps slc3a2.S, anticorps slc3a2a, anticorps slc3a2b
Sujet
Solute carrier family 7 member 5,CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.,4F2, MDU1, 4F2HC, 4T2HC, NACAE, SLC3A2