LAT2 anticorps (AA 196-212)

N° du produit ABIN94442

Détail du produit anti-LAT2 anticorps

Antigène: LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))

Épitope: AA 196-212

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LAT2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: The antibody NAP-03 recognizes a defined intracellular epitope (aa 196-212) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B cells, NK cells and myeloid cells.

Aucune reactivité croisée: Souris

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Peptide corresponding to aa 196-212 of human NTAL coupled to KLH.

Clone: NAP-03

Isotype: IgG2a

Information d'application

Indications d'application: Immunohistochemistry (paraffin sections): Recommended dilution: 5 μg/mL, positive tissue: tonsil, germinal center.
Western blotting: Recommended dilution: 1-2 μg/mL, incubation 60 min, positive control: RAMOS human lymphoma cell line, non-reducing conditions, 12 % separating SDS-PAGE gel.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-LAT2 (ABIN94442)

Brdicka, Imrich, Angelisová, Brdicková, Horváth, Spicka, Hilgert, Lusková, Dráber, Novák, Engels, Wienands, Simeoni, Osterreicher, Aguado, Malissen, Schraven, Horejsí: "Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." dans: The Journal of experimental medicine, Vol. 196, Issue 12, pp. 1617-26, (2002) (PubMed).

Détails sur LAT2

Antigène: LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))

Autre désignation: NTAL / LAB (LAT2 Produits)

Synonymes: anticorps LAB, anticorps NTAL, anticorps WBSCR15, anticorps WBSCR5, anticorps WSCR5, anticorps LAT2, anticorps MGC139435, anticorps Ntal, anticorps Wbscr5, anticorps AW125574, anticorps Wbscr15, anticorps linker for activation of T-cells family member 2, anticorps linker for activation of T cells family, member 2, anticorps LAT2, anticorps Lat2

Sujet: Linker for activation of T cells family member 2,NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.,LAB, LAT2

ID gène: 7462

UniProt: Q9GZY6

Pathways: Fc-epsilon Receptor Signaling Pathway, BCR Signaling