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STAT1 anticorps

STAT1 Reactivité: Humain WB, IP Hôte: Souris Monoclonal SM2 unconjugated
N° du produit ABIN94469
  • Antigène Voir toutes STAT1 Anticorps
    STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
    Reactivité
    • 209
    • 121
    • 83
    • 24
    • 18
    • 16
    • 15
    • 13
    • 11
    • 10
    • 7
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 188
    • 39
    • 2
    Souris
    Clonalité
    • 165
    • 64
    Monoclonal
    Conjugué
    • 126
    • 11
    • 11
    • 9
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp STAT1 est non-conjugé
    Application
    • 150
    • 67
    • 55
    • 54
    • 39
    • 32
    • 27
    • 26
    • 26
    • 12
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Specificité
    The antibody SM2 recognizes an epitope included within amino acids 8-23 of STAT1, a 91 kDa transcriptional factor involved in a variety of systems including antiviral responses and interferon alpha (IFN-alpha) and gamma (IFN-gamma) signal transduction.
    Réactivité croisée (Details)
    Other not tested, Human
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    STAT1 peptide sequence 8-23 (QLDSKFLEQVHQLYD) conjugated to KLH.
    Clone
    SM2
    Isotype
    IgG1
    Top Product
    Discover our top product STAT1 Anticorps primaire
  • Indications d'application
    Western blotting: Recommended dilution 1-2 μg/mL, reducing conditions.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Antigène
    STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
    Autre désignation
    STAT1 (STAT1 Produits)
    Synonymes
    anticorps CANDF7, anticorps ISGF-3, anticorps STAT91, anticorps 2010005J02Rik, anticorps AA408197, anticorps XStat1, anticorps STAT4, anticorps DD6G4-4, anticorps STAT, anticorps STAT1, anticorps dZ182H3.3, anticorps si:by134g18.2, anticorps si:by51f19.1, anticorps si:dz182h3.3, anticorps si:dz199m19.1, anticorps si:dz73o4.2, anticorps stat1, anticorps signal transducer and activator of transcription 1, anticorps signal transducer and activator of transcription 1 L homeolog, anticorps signal transducer and activator of transcription 1, 91kDa, anticorps signal transducer and activator of transcription 4, anticorps signal transducer and activator of transcription 1a, anticorps STAT1, anticorps Stat1, anticorps stat1.L, anticorps stat4, anticorps stat1a
    Sujet
    Signal transducer and activator of transcription 1,STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest, apoptosis promoting and tumour suppression. After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2, dimerizes, translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is also phosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation. However, the both modifications are important for its maximal transcriptional activity. On the other hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation.,CANDF7, IMD31, ISGF3
    ID gène
    6772
    UniProt
    P42224
    Pathways
    Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
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