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C6orf150 anticorps (Middle Region)

C6orf150 Reactivité: Humain WB, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN950947
  • Antigène Voir toutes C6orf150 Anticorps
    C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
    Épitope
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 273-303, Middle Region
    Reactivité
    • 29
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 32
    • 1
    Lapin
    Clonalité
    • 32
    • 1
    Polyclonal
    Conjugué
    • 16
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp C6orf150 est non-conjugé
    Application
    • 27
    • 17
    • 7
    • 7
    • 6
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    This antibody recognizes Human C6orf150 (CF150). Other species not tested.
    Purification
    Affinity chromatography on Protein A
    Immunogène
    KLH conjugated synthetic peptide between 273-303 amino acids from the Central region of human CF150
    Isotype
    Ig Fraction
    Top Product
    Discover our top product C6orf150 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS, 0.09 % (W/V) Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
    Autre désignation
    C6orf150 (C6orf150 Produits)
    Synonymes
    anticorps C6orf150, anticorps cGAS, anticorps h-cGAS, anticorps Mab-21 domain containing 1, anticorps cyclic GMP-AMP synthase, anticorps MB21D1, anticorps CGAS
    Sujet
    Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Cellular Location: Cytoplasm, cytosol. Tissue Location: Expressed in the monocytic cell line THP1.Synonyms: Uncharacterized protein C6orf150
    Poids moléculaire
    58814 Da
    ID gène
    115004
    NCBI Accession
    NP_612450
    Pathways
    Activation of Innate immune Response
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